LSU vs Oklahoma
Sooners to survive in Norman, but the Tigers won’t go quietly.

LSU (7-4) VS OKU (9-2)
November 29, 2025 | 3:30 p.m. ET | Gaylord Family-Oklahoma Memorial Stadium, Norman, OK


Oklahoma enters on a three-game heater after navigating a brutal November stretch against Tennessee, Alabama, and Missouri, while LSU has steadied under interim coach Frank Wilson with back-to-back wins following a three-game skid and Brian Kelly’s firing. Both defenses are legitimately top-25 units in scoring and total yardage allowed, but the Sooners’ profile is a touch nastier, giving up just about two touchdowns per game with an elite run defense, against an LSU offense that has struggled to run the ball or finish drives in the red zone all season. Quarterback injuries swing the matchup toward the home side: Garrett Nussmeier, who torched Oklahoma for 277 yards and three scores last year, is doubtful and effectively out with an abdominal issue, so Michael Van Buren Jr. is set for a third straight start, whereas John Mateer is healthy again and just engineered that 17-6 win over Missouri. LSU also has a banged‑up left tackle (Tyree Adams) and a nicked-up feature back in Caden Durham, while Oklahoma’s key absences are on the edge (R Mason Thomas, doubtful) and in the “cheetah” rotation, which matter but don’t change the fundamental talent and continuity edge for the Sooners at home in a must‑win College Football Playoff spot. Given the combination of Oklahoma’s defensive floor, LSU’s backup quarterback situation, and OU’s home-field advantage with everything on the line, I like Oklahoma to win outright but at a steep price, so the recommendation is a moneyline play on Oklahoma at -500, graded a B for strong win probability but limited value. Odds and availability are subject to change. This bet was made at 28/11/2025 11:11am
The total is parked at 36.5 for a reason: Oklahoma hasn’t topped 360 yards of offense since mid-September and just ground out a 17-6 rock fight against Missouri, while LSU’s attack has become even more conservative with Van Buren under center, scoring 23 and 13 points in his two starts as the Tigers leaned heavily on their defense. Both teams rank in the bottom half of FBS in scoring offense but inside the top 25 nationally in scoring defense, with the Sooners smothering the run and LSU quietly fielding a balanced unit that has kept five of its last six opponents under 205 passing yards; combine that with LSU’s mediocre red-zone efficiency and Oklahoma’s top-10 third-down and scoring defense, and sustained drives and explosive plays should both be at a premium. The quarterback and injury setup also favors a slower, lower game: LSU is unlikely to fully trust Van Buren on the road in Norman against a front that leads the nation in late-game sacks and QB hits, and Oklahoma is short on healthy running backs, which has already pushed Mateer into more scrambling and clock‑draining, risk‑averse game scripts rather than wide-open tempo. With the Sooners playing to protect a CFP berth and LSU trying to shorten the game as a spoiler, projections in the low 30s (something like 24-10 or 20-13) make Under 36.5 at -128 my preferred total angle, and I’ll grade it a B+ thanks to the strong matchup fit despite the low number and juiced under. Odds and availability are subject to change. This bet was made at 28/11/2025 11:11am
Against the number, though, LSU +10.5 is more attractive than laying double digits with an Oklahoma offense that’s been outgained in four straight games and has mostly lived on its defense during this three-game winning streak. The Tigers’ defense has traveled all year and sits top-25 in scoring, total, run, and pass defense, plus top-25 nationally in turnover margin, which is exactly the profile you want from a big road underdog trying to stay inside the number; they already showed last year they understand how to attack Brent Venables’ scheme when Caden Durham gashed the Sooners on the ground and Nussmeier hit explosive shots, and while the quarterback is different, Van Buren has managed games well with a 63% completion rate and just one pick over his two starts. Oklahoma’s pass rush is still dangerous, but losing edge rusher R Mason Thomas and having to sit Reggie Powers for the first half trims some of that late-down juice, and if Adams is able to go at left tackle and Durham is close to full strength, LSU’s offense should be just competent enough to avoid the avalanche drives that broke this open a year ago. With the Sooners likely to lean on their defense, run game, and Mateer’s legs in a high-pressure, CFP-berth environment, the script points to a methodical Oklahoma win that still gives LSU enough possessions for a backdoor or wire-to-wire cover, so I’m grabbing LSU +10.5 at -116 and grading it a B+ based on the matchup, the number, and the Tigers’ defensive ceiling. Odds and availability are subject to change. This bet was made at 28/11/2025 11:11am
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