NFL

49ers vs Seahawks

Old rivals clash, but one edge keeps flashing brighter.

San Francisco 49ers

SF (0-0) VS SEA (0-0)

09/07/2025 | 3:05 PM ET | Lumen Field, Seattle, WA

Seattle Seahawks
Moneyline Pick - San Francisco 49ers (-120): Grade B

San Francisco comes into this divisional clash with multiple repeatable advantages. Their quarterback has already shown comfort in this venue, translating strong efficiency into road wins, while Seattle’s offense has struggled to sustain drives in recent divisional matchups. The 49ers’ pass rush remains one of the league’s most disruptive, and history suggests it can again move Seattle’s quarterback off rhythm. Combined with Shanahan’s proven track record against Carroll, the matchup tilts toward the visitors having both the schematic and personnel edge in a setting where they’ve consistently delivered results.

From a betting perspective, San Francisco is the sharper pick. Their combination of continuity, proven divisional dominance, and a defensive front that creates mismatches makes them the more reliable side despite the road environment. Seattle has paths to compete, but the balance of trends and head-to-head success favors the 49ers. It’s a play based on sustained patterns rather than short-term streaks, making San Francisco the practical choice.

This prediction gets a B grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 07/10/2025 at 9:34am

Over/Under Pick - Under 43.5, (-110): Grade B+

This matchup projects more as a grind than a shootout, with both teams structured around controlling tempo and limiting mistakes. San Francisco’s secondary tightened up late last season, reducing opponents’ efficiency through the air, while Seattle’s offense never fully found rhythm down the stretch. With both backfields built to handle volume, sustained drives should chew clock and cap total possessions. Favorable weather removes volatility, but history between these two rivals already leans toward lower-scoring outcomes, and Week 1 tendencies from both coaching staffs further support a cautious approach.

From a betting standpoint, the under is the sharper side. Trends from recent meetings, paired with each team’s reliance on run-heavy balance and defensive discipline, make it difficult to project a total climbing into the mid-40s. Even if one drive produces an explosive play, the overall game script points to long possessions and red-zone resistance. It’s a prediction rooted in matchup style and historical precedent, making the under the practical play here.

This prediction gets a B+ grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 07/10/2025 at 9:36am

Spread Pick - San Francisco 49ers, -1.5 (-105): Grade B

San Francisco carries both matchup advantages and proven road reliability into this divisional spot. Their offense has consistently produced with Purdy under center, and Seattle’s vulnerability against the run directly plays into the hands of a backfield designed to control games. Defensively, the 49ers enter healthier and deeper in the secondary, with added talent to handle Seattle’s top receiving threats. That combination of efficient scoring and defensive reinforcement tilts the prediction toward the visitors being able to manage the matchup and secure a narrow but comfortable edge.

From a betting perspective, San Francisco -1.5 is the sharper side. The number essentially calls for the 49ers to win outright, and their balance of offensive firepower and defensive discipline provides multiple paths to cover. With recent ATS success on the road and matchup-specific strengths against Seattle’s weaknesses, the probability favors the visitors. It’s a play supported by both trend data and roster construction, making San Francisco the practical choice.

This prediction gets a B grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 07/10/2025 at 9:37am

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