Saint Louis vs Duquesne

Saint Louis rolls into Pittsburgh on an 11-game winning streak and a 17-1 overall mark, while Duquesne has dropped three of its last four despite a needed bounce-back win at Fordham, making the Billikens justifiably heavy favorites on the moneyline.([cbssports.com](https://www.cbssports.com/college-basketball/gametracker/preview/NCAAB_20260120_STLOU%40DUQ?utm_source=openai)) With Saint Louis essentially injury-free aside from redshirting forward Kalu Anya, and Duquesne listing rotation guards Ethan Anish, Seamus McDermott, and Lucas Prolla as questionable, the depth picture slightly tilts further toward the road side.([covers.com](https://www.covers.com/sport/Basketball/ncaab/matchup/370908/injuries?utm_source=openai)) The Avila–Brown–McCottry core for Saint Louis has driven one of the nation’s most efficient, balanced attacks, while Duquesne leans heavily on Tarence Guinyard, Jimmie Williams, and John Hugley IV to keep pace, a trio that has scored well but hasn’t consistently cracked top-tier defenses like this Billikens unit.([espn.com](https://www.espn.com/mens-college-basketball/game/_/gameId/401828382/saint-louis-duquesne?utm_source=openai)) Even knowing last year’s 90–88 Saint Louis overtime win showed Duquesne can scrap, the combination of the Billikens’ defensive numbers, road form, and superior depth makes laying the -550 moneyline a high-confidence but low-value position that I grade as a B+ recommendation. Odds and availability are subject to change. This bet was made at 20/01/2026 09:45.

Duquesne’s fast-paced, shot-making offense and leaky defense — averaging mid‑80s on offense while allowing the high‑70s — pairs with a Saint Louis group scoring just under 92 points per game and winning by roughly 25 per night, creating a statistical profile that naturally leans toward a high total.([espn.com](https://www.espn.com/mens-college-basketball/game/_/gameId/401828382/saint-louis-duquesne?utm_source=openai)) With Saint Louis healthy outside of Anya’s season-long redshirt and Duquesne’s questionable guards more likely to trim the rotation than mute the tempo entirely, neither side projects as notably hampered in terms of pace or perimeter creation.([covers.com](https://www.covers.com/sport/Basketball/ncaab/matchup/370908/injuries?utm_source=openai)) Key offensive engines like Robbie Avila and perimeter threats Trey Green and Amari McCottry for Saint Louis, plus Guinyard’s on‑ball scoring and the supporting firepower of Hugley and Williams for Duquesne, all point toward both teams maintaining efficient shooting and volume from three, especially given Duquesne’s strong home splits.([bleachernation.com](https://www.bleachernation.com/picks/2026/01/20/saint-louis-vs-duquesne-prediction-spread-total-points-moneyline-picks-tuesday-january-20-2026/?utm_source=openai)) Historical meetings between these programs have frequently pushed into the 140s and 150s and beyond, and with both offenses better than a year ago, I lean Over 166.5 despite the aggressive number, grading it a high‑ceiling but volatile C+ play. Odds and availability are subject to change. This bet was made at 20/01/2026 09:45.

Robbie Avila’s inside‑out scoring and playmaking for Saint Louis headline a roster that has gone 10-6 against the number while routinely posting blowout margins, now facing a Duquesne team that sits below .500 ATS and has struggled to contain efficient offenses.([oddsshark.com](https://www.oddsshark.com/stats/team/basketball/ncaab/15235?utm_source=openai)) The Billikens’ 11-game win streak and elite defensive metrics contrast with a Dukes squad that, while 8-3 at home, just snapped a skid of three losses in four games, suggesting their recent momentum is more fragile than Saint Louis’ sustained trajectory.([cbssports.com](https://www.cbssports.com/college-basketball/gametracker/preview/NCAAB_20260120_STLOU%40DUQ?utm_source=openai)) With Saint Louis effectively at full strength apart from Anya and Duquesne potentially down a few depth guards, the front-line matchup of Avila, Dion Brown and Kellen Thames against Hugley, Jakub Necas and Guinyard favors the deeper, more physical Billikens, even acknowledging last season’s razor-thin 90–88 finish.([covers.com](https://www.covers.com/sport/Basketball/ncaab/matchup/370908/injuries?utm_source=openai)) Given Saint Louis’ capacity to string together stops and turn defense into transition points, laying -9.5 at -120 earns a solid B grade for combining a strong likelihood of covering with a still reasonable price compared to the inflated moneyline. Odds and availability are subject to change. This bet was made at 20/01/2026 09:45.