MLB

Cardinals vs Cubs

Windy City hopes breeze past Redbird resistance.

St. Louis Cardinals

Cardinals (78-81) VS Cubs (89-69)

Sep 26, 2025 | 2:20 PM ET | Wrigley Field, Chicago

Chicago Cubs
Moneyline Pick - Chicago Cubs (-178): B

Chicago brings both the statistical edge and the motivational edge into this divisional clash, making them the more reliable side. Their rotation has delivered steady outings against this opponent, while the bullpen has been one of the most effective groups in the league this month. St. Louis, conversely, is operating without key pieces and has little left to play for, leaving its thinner relief corps exposed in late innings. With Chicago still focused on postseason positioning, their sharper form and urgency make them the logical prediction, and the moneyline stands as the cleaner pick despite the cost.

From a betting perspective, the high price does temper appeal, but sometimes the best play is to side with stability. Chicago’s recent consistency in run prevention pairs with meaningful stakes to give confidence in their ability to finish the job. While divisional underdogs can always surprise, the situational profile tilts strongly toward the Cubs, making this bet more about reducing risk than chasing big returns. The pick is on Chicago to handle business, even if the payout is modest.

This prediction gets a B grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 09/26/2025 at 9:00am

Over/Under Pick - Over 9 (100): B-

The setup at Wrigley points toward offense, with pitching conditions unlikely to suppress scoring. Chicago has consistently hit well at home, and the forecasted winds only add to their ability to lift the ball into the gaps or over the fence. St. Louis, despite its struggles, has certain lineup strengths that match up well against the Cubs’ starter, giving them a chance to contribute to the total. With both bullpens stretched thin from recent workload, mid-relief arms are more likely to be tested, which historically boosts run production. All told, the environment suggests the Over is the stronger prediction, making it the pick to consider.

From a betting perspective, this isn’t just about wind or ballpark quirks—it’s also about game flow. Overworked bullpens create higher-variance innings, and with neither side eager to burn its freshest arms late in September, extra offense can sneak through. Add in two starters who don’t dominate this particular matchup, and the path to runs feels realistic. Backing the Over aligns with both situational and statistical indicators, making this bet a logical way to attack the game.

This prediction gets a B- grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 09/26/2025 at 9:00am

Spread Pick - Chicago Cubs, -1.5 (-115): B

Chicago’s profile makes the run line a viable play, as their wins have consistently come by comfortable margins. Their starter’s ability to work deep into games limits bullpen exposure, and the offense has shown a knack for late separation, ranking among the league’s best in final-frame production. St. Louis, by contrast, has struggled to generate consistent road power, and their thinned lineup has left them short of the punch needed to keep pace. Against a starter who has fared well in this matchup, the conditions support a prediction that Chicago can extend beyond a one-run edge, making the run line a reasonable pick.

From a betting perspective, this option offers slightly better value than the straight moneyline without straying into excessive risk. The Cardinals’ road struggles, paired with the Cubs’ late-inning strength, create multiple avenues for a two-run result. Still, September variance and divisional familiarity introduce some caution, preventing this from reaching top confidence. Even so, the bet leans toward Chicago delivering another decisive win, and the pick favors their run line.

This prediction gets a B grade. Odds and availability subject to change. Follow Shurzy on Instagram and Tiktok for more expert picks.

This bet was made on 09/26/2025 at 9:00am

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