NFL

Jaguars vs Colts

Hot Jaguars hunt reeling Colts in high-stakes Lucas Oil showdown.

Jacksonville Jaguars

JAX (11-4) VS IND (8-7)

December 28, 2025 | 1:00 PM ET | Lucas Oil Stadium, Indianapolis, IN

Indianapolis Colts
Moneyline Pick - Jacksonville Jaguars (-300): B
Trevor Lawrence and the Jaguars roll into Indianapolis on a six-game heater against a Colts team that has dropped five straight and six of seven, with those trends reflected in Jacksonville’s 11-4 mark versus Indy’s 8-7. With Lawrence in rhythm and fresh off a clean, efficient 244-yard, 2-TD outing in the 36-19 Week 14 win over these same Colts, Jacksonville’s offense looks far more stable than an Indianapolis attack now leaning on 44-year-old Philip Rivers after Daniel Jones’ injury and a prolonged slump. Add in Jacksonville’s recent dominance of the series, the Jags’ top-tier scoring margin versus a Colts defense that just surrendered 48 points at home, and a slightly banged-up Indianapolis front (notably DeForest Buckner and multiple linemen on the injury report), and the matchup tilts strongly toward the visitors even in the Colts’ friendly confines. The price at -300 isn’t cheap, so in terms of value this is more of a parlay anchor than a standalone play, but the combination of form, quarterback edge, and clear AFC seeding motivation for Jacksonville versus Indy’s near-elimination status makes the Jaguars Moneyline a solid B-grade position. Odds and availability are subject to change. This bet was made at 26/12/2025 11:38
Over/Under Pick - Over 48.5, (-110): B
This total hinges on whether the Colts can keep up with a Jacksonville offense averaging around four touchdowns per game over its six-game win streak and already having hung 36 on Indy earlier this month. The Jaguars’ passing game with Lawrence and a versatile back like Travis Etienne has consistently stressed defenses at all three levels, and the Colts have recently bled explosive plays, allowing 23+ points repeatedly and then 48 to San Francisco, while also struggling to get off the field late. On the other side, Indianapolis still has enough juice with Jonathan Taylor and a deep receiving corps (Alec Pierce, Michael Pittman Jr.) to exploit a Jacksonville defense that comes in a bit nicked in the secondary and could be more vulnerable indoors without weather as a disruptor. Given the previous 55-point meeting, both teams’ season scoring profiles (high-20s per game on average), and the urgency factor with playoff seeding and survival in play, the Over 48.5 at -110 earns a B: not a smash, but a worthwhile play expecting the Jags to drive the pace and the Colts to do just enough to push this into the low-50s. Odds and availability are subject to change. This bet was made at 26/12/2025 11:38
Spread Pick - Jacksonville Jaguars, -6.5 (-110): B+
Jacksonville -6.5 profiles as the sharper side after the Jaguars comfortably covered as short home dogs in that 36-19 win over the Colts and have since run their ATS streak to six straight, while Indianapolis has failed to cover in a five-game skid that’s exposed depth issues and defensive cracks. Lawrence’s comfort against this scheme, Etienne’s multi-score impact in the last matchup, and Jacksonville’s defensive front getting a plus matchup versus a Colts line dealing with multiple injuries all suggest the Jags can again create separation, especially if Rivers is forced into a higher-volume script and late-game mistakes. With Jacksonville chasing seeding (and still in the mix near the top of the AFC) and Indy on the brink of elimination, the motivational edge also tilts to the road favorite, making a one-score spread more palatable than laying a steep Moneyline price. At -6.5 and -110, the combination of recent dominance in the matchup, contrasting streaks, and personnel edges yields a B+ grade on the Jaguars against the number. Odds and availability are subject to change. This bet was made at 26/12/2025 11:38
Share this post

Get the best odds on this prediction

Use our Live Odds Tool to get the best price on your favourite picks