Arizona Cardinals vs Los Angeles Rams

The Rams have won three of their last five while the Cardinals are riding an eight-game losing streak and have dropped 15 of their last 18 against Los Angeles, making this matchup a clear contrast in current form and historical head-to-head results. With Arizona already eliminated and jockeying for draft position while the Rams still have NFC wild-card seeding at stake, motivation strongly favors Sean McVay’s group. Significant injuries further tilt the scale: Arizona is without top wideout Marvin Harrison Jr. and has star safety Budda Baker banged up, weakening both their vertical passing game and back-end defense, while Los Angeles’ biggest concern is Davante Adams’ hamstring but they still lean on a healthy core of Matthew Stafford, Puka Nacua, and Kyren Williams. In a controlled SoFi Stadium environment and with Stafford having lit up this defense in a 45-17 road win just a month ago, I’m laying the juice and backing the Los Angeles Rams moneyline at -350, grading it an A- due to high win probability but limited payout. Odds and availability are subject to change. This bet was made at 02/01/2026 11:55

The total sets up for points: the Rams lead the league at roughly 30.5 points per game while the Cardinals sit around 21.4, and both defenses have been vulnerable, with Arizona allowing nearly 28 points per game and ranking in the bottom tier against both run and pass. Recent trends reinforce the offensive outlook, as the Cardinals have gone over the total in 8 of their last 12 and the Rams have hit overs in five straight behind Stafford’s MVP-caliber passing and explosive performances from Nacua and Kyren Williams. Arizona’s defense is further compromised without Harrison Jr. to help them sustain drives and with a battered front seven, which can lead to shorter fields and more Rams possessions, while Jacoby Brissett has quietly kept the Cardinals offense competent enough to contribute to a shootout script. The main risk is Los Angeles pulling starters late if they build a big lead, but given both teams’ scoring profiles and recent over trends, I like Over 46.5 at -110 with a B+ grade for a strong but not slam-dunk angle. Odds and availability are subject to change. This bet was made at 02/01/2026 11:55

Against the spread, the Rams are in far better shape, having gone 14-5 ATS in their last 19 while Arizona is 1-7 ATS over its last eight and just 4-13-1 ATS in its past 18 meetings with Los Angeles, including last month’s 45-17 Rams rout. The Cardinals limp in with a long losing streak and major personnel issues — no Marvin Harrison Jr. on offense and a defense missing or limiting multiple starters — which puts extra pressure on Brissett to keep pace with Stafford, Nacua, and a balanced Rams attack that ranks top two in yardage and first in scoring. Los Angeles does have its own injury concerns with Adams and several linemen on the report, and there is always Week 18 risk that McVay manages snap counts with a wild-card spot already clinched, creating some backdoor-cover potential on the key 7.5 number. Even so, with a talent gap, home-field edge at SoFi, and playoff seeding motivation on the Rams’ side versus a Cardinals team largely playing out the string, I’m laying the -7.5 at -110 and grading it a B+: solid value as long as Los Angeles doesn’t go ultra-conservative late. Odds and availability are subject to change. This bet was made at 02/01/2026 11:55